Antidepressant can cause insomnia

Bupropion has several side effects and most will go away after a short term.


May 4, 2020 - 9:05 AM

Dear Dr. Roach: My doctor started me on Wellbutrin 150 mg XL for depression, but I have had terrible insomnia. She said it would get better in two to four weeks, but I am having severe anxiety due to not sleeping. Do you have any suggestions? — N.M.N.

Answer: Bupropion (Wellbutrin) is an antidepression medicine in another kind of class from medicines like Prozac or Celexa, which are SSRIs and have a very different side-effect profile. Bupropion seldom causes the sexual side effects often noted with SSRIs, and more often causes weight loss than weight gain.

However, bupropion must be used with extreme caution or not at all in people with a seizure disorder. Other side effects include dry mouth, nausea or dizziness, and your doctor is right that most often these will go away within the two to four weeks she mentioned.

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